COVID-19; Immunology, pathology, severity and immunosuppressants

As most COVID-19 patients show mild to moderate symptoms; 15% suffer from severe respiratory symptoms, and 5% develop acute distress syndrome which may be associated with multiple organ failure. The highly virulent SARS-CoV-2 affects organs, other than lungs, such as brain, kidney, cardiovascular system gastrointestinal tract. This review highlights the relation between involvement. causes cytokine storm damage of lung cells activation NF-?B, hence reach organs that leads death in some cases. current discusses factors affecting severity including immune response storm, smoking, gender blood group. also genetic cases, alongside comorbid diseases diabetes, obesity. Also, this focuses on effect immunosuppressants antirheumatic drugs protection treatment